ABSTRACT
Context: Autism prevalence is increasing, with current estimates at 1/68–1/50 individuals diagnosed with autism. Diagnosis is based on behavioral assessments. Early diagnosis and intervention are known to greatly improve functional outcomes in people with autism. Diagnosis, treatment monitoring, and prognosis of autistic children's symptoms could be facilitated with biomarkers to complement behavioral assessments. Aims: The aim of this study is to compare and evaluate salivary zinc concentration in saliva samples of autistic and healthy children in mixed dentition age group. Settings and Design: Cross-sectional comparative study carried out in dental college and special child school. Unstimulated whole saliva collected for finding a biomarker. Subjects and Methods: Unstimulated whole saliva sample was collected from 10 autistic and 10 healthy children in mixed dentition age group. Diluted saliva sample was then subjected to inductively coupled plasma emission spectroscopy for the estimation of salivary zinc concentration. Statistical Analysis Used: Mann–Whitney U-test. Results: In children with autism salivary zinc concentration showed a linear equation when compared to healthy children. Conclusions: The low salivary zinc concentration in autistic children can reveal the pathogenesis of autism.
ABSTRACT
The word, Ayurveda in Sanskrit roughly means the “science or knowledge of life.” Other Ayurvedic experts however, contend that Ayurveda is even more accurately translated as the “science or knowledge of longevity.” As such, it focuses on comprehensively addressing the body and preventing disease by reestablishing equilibrium. When balance is achieved, longevity – living a long, healthy, active and productive life – can be obtained(Frawley D.1989., Svoboda RE 1989). Medicinal plants represent a rich source of antimicrobial agents. Plants are used medicinally in the different countries and are a source of many potent and powerful drugs(Srivastava J et al., 1996). In this study the Antimicrobial activity of ‘Embelia Basal’ in acetone extracts were compared with Chlorhexidine and Amoxicillin 125mg and Amoxicillin 250mg against human salivary microfloraat different concentrations. The antimicrobial activity was assisted by measuring the inhibition zones by well diffusion method. Saliva was collected from children of age group 6-12 years having DMFT value four or above four. Ten salivary samples were tested for antimicrobial property to determine the Minimum Inhibition Concentration in order to increase the reliability and precision of the study. The results confirmed the antimicrobial potential of ‘Embeiia Basal’ plant at different concentrations in acetone extracts are comparable with chlorhexidine and Amoxicillin and can be used as preventive and therapeutic measure in dentistry.